Radiesse® is a sterile, latex-free, injectable implant, whose principal component is synthetic calcium hydroxylapatite, a biocompatible material with over 20 years of use in medicine. The product has FDA approval for esthetic facial augmentation in the US. Such approval includes the long-lasting correction of moderate to severe facial wrinkles and folds and the treatment of facial fat loss due to immunodeficiency virus infection. Diverse facial regions can be injected in order to restore or enhance some features: glabellar lines, cheek fat pads, tear troughs, nasolabial folds, nose, lips, perioral region, marionette lines, and chin among others, as well as acne scars. The average lasting result is from 12 to 18 months. Radiesse® can be considered an effective soft-tissue filler for overall longevity, biocompatibility, and low rate of side effects.